bikecompat

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No

Is the SRAM 12-speed AXS chain (Flattop) compatible with a Shimano 12-speed drivetrain?

No. SRAM Flattop is a proprietary chain (taller, with different links) designed for SRAM 12-speed AXS road groupsets and the XDR cassette. It is not interchangeable with the Shimano 12-speed chain (HG+), nor with SRAM Eagle 12-speed MTB, nor with Campagnolo 12-speed.

Standards involved

SRAM Flattop (12-speed AXS road) A proprietary SRAM chain for 12-speed AXS road groupsets (Red/Force/Rival): taller, with different links. Shimano 12-speed (HG+ / Hyperglide+) Shimano 12-speed chain/cassette. The road lines (105/Ultegra/Dura-Ace 12-speed) and MTB lines use dedicated chains.

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Related questions

Source: SRAM / Shimano. Indicative data — always check the manufacturer's official specs.